Amgen’s bispecific T-cell engager (BiTE) led to an ORR of 41% in patients with extensive-stage small cell lung cancer.
Sacituzumab tirumotecan is under clinical development by Merck and currently in Phase II for Peritoneal Cancer.
Sotorasib is under clinical development by Amgen and currently in Phase II for Solid Tumor. According to GlobalData, Phase II drugs for Solid Tumor have a 37% phase transition success rate (PTSR) ...
Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India ...
The drug is an antineoplastic agent that acts by blocking the activity of hypoxia-inducible factor 2 alpha (HIF-2α), which regulates cellular proliferation, angiogenesis, and tumor growth.