The tension elevation activated the mechanosensitive ion channel Tmem63b and triggered Ca 2+ influx, leading to actomyosin activation at the rear of the cell. Blockade of this signaling pathway ...

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More information: Jianmin Yin et al, Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1, Nature Communications (2024).

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team has uncovered new mechanisms in blood vessel formation.

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team at the Biozentrum of the University of Basel ...