While pericytes are important regulators of capillary function and homeostasis, the lack of specific markers has hampered the ...

Identifying target proteins for bioactive molecules is essential for understanding their mechanisms, developing improved derivatives, and minimizing off-target effects. Despite advances in target ...

The American Culture Quiz is a weekly test of our unique national traits, trends, history and people, including current events and the sights and sounds of the United States. This week's quiz ...

City of Hope scientists have identified a protein, YTHDF2, that helps cancer cells evade CAR T cell therapy. They developed a drug, CCI-38, to inhibit YTHDF2, enhancing CAR T cell effectiveness ...

Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States Center for Synthetic Biology, Northwestern University, Evanston, Illinois 60208, ...

Protein engineering enables the creation of tailor-made proteins for a variety of ... Among the latter, one such class of therapeutic molecules is the immune mobilizing monoclonal T-cell receptor (TCR ...

the two cells have different histone modifications and other regulatory proteins, allowing the expression of unique sets of genes in each. If this regulation goes awry, it can lead to serious ...

Scientists at City of Hope have collared a tricky culprit that helps cancer cells evade CAR T cell therapy. CAR T cell therapy harnesses the immune system to seek out and kill tumor cells.