1Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate ...

Bakuchiol inhibited DNA replication and activated the checkpoint kinase CHK1 by targeting DNA polymerases. Isobavachalcone interfered with DNA double-strand break (DSB) repair by inhibiting the ...

Emotional dependence involves relying on your partner to meet the majority or all of your needs. When you experience distress, you might look to them immediately before trying to manage your ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neural stem cells (NSCs) can give rise to both ...

There are currently no approved CDK2 specific drugs. ETX-197/BG-68501 was designed through ENSEM’s Kinetic Ensemble platform to induce previously unexplored interactions within the CDK2 ATP ...

Provided herein are novel compounds as CDK2 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds. Cyclic-dependent kinase 2 ...