NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

including tests on cell cultures expressing recombinant COX-1 or COX-2 enzymes and whole-blood assays measuring the production of either thromboxane by platelets (an index of COX-1 activity ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition ... NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...

Medically reviewed by Marissa Sansone, MD Ibuprofen and meloxicam are both nonsteroidal anti-inflammatory drugs (NSAIDs) that ...

COX-2 is involved in prostaglandin synthesis and expressed ... may be another important player in neural aspects of the inflammatory response. Figure 1: Regulatory checkpoints of peripheral ...