The zygote that results from fertilization inherits one nuclear allele of each gene from each parent (that is, at the three example loci, it is Aa, Bb and Cc). By contrast, the cytoplasmic ...

The SMN protein localizes to both the cytoplasm and the nuclear bodies. One hallmark of spinal muscular atrophy is the failure of SMN to localize within these nuclear bodies. A recent study has ...