As humans do not synthesize dTDP-l-rhamnose, the four enzymes of its metabolic pathway represent very appealing targets against which new drugs might be designed. Analysis of V. cholerae mutants ...

In MTCH2-deleted NIH3T3L1 cells, AMP levels increase, similar to what is observed in HeLa cells, likely due to: (1) alterations in nucleotide metabolism (AMP, ADP, ATP), a common phenotype associated ...

a FDA = Food and Drug Administration; CYP2C9 = cytochrome P-450 isoenzyme 2C9; VKORC1 = vitamin K epoxide reductase complex subunit 1; UGT1A1 = uridine diphosphate-glucuronosyltransferase 1A1 ...

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Translational Data Analytics Institute, The Ohio State University, Columbus, Ohio 43210, United States ...