Activation of Sirt1 potentiated the profibrotic effects of TGF-β with increased Smad reporter activity, elevated transcription of TGF-β target genes and enhanced release of collagen. In contrast, ...

Further analysis revealed that PDE4 inhibition decreased the differentiation of M2 macrophages and the release of several profibrotic cytokines, resulting in reduced fibroblast activation and collagen ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

Keywords: endoglin, peritoneal fibrosis, angiogenesis, EMT, TGF-β/ALK/Smads Citation: Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J and Wang H (2024) Corrigendum: Endoglin aggravates peritoneal ...

Through tissue tension, stretching promotes fibroblast activity and macrophage polarization, further amplifying anti-inflammatory responses. Together, these interventions strengthen macrophage ...

Effect of C7-T1 Extensional Posterior Transpedicle Osteotomy on Mobility and Quality of Life in Patients with Ankylosing Spondylitis Complicated with Lumbar Kyphosis and Related Factors.

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

哺乳动物中存在三种高度同源的TGF-β亚型，即TGF-β1、TGF-β2、TGF-β3。在TGF-β超家族中，TGF-β亚型的研究最为广泛。根据癌症基因组图谱（TCGA ...