The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

Keywords: endoglin, peritoneal fibrosis, angiogenesis, EMT, TGF-β/ALK/Smads Citation: Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J and Wang H (2024) Corrigendum: Endoglin aggravates peritoneal ...

哺乳动物中存在三种高度同源的TGF-β亚型，即TGF-β1、TGF-β2、TGF-β3。在TGF-β超家族中，TGF-β亚型的研究最为广泛。根据癌症基因组图谱（TCGA ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

Human lung fibroblasts ... lung fibroblast activation and decrease the deposition of extracellular matrix proteins after stimulation with the well-known fibrotic mediator TGF-β1.

This important study suggests that the composition of the extracellular matrix in a mouse model of liver fibrosis changes depending on the cause of liver fibrosis. The data could be used as a ...