The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

哺乳动物中存在三种高度同源的TGF-β亚型，即TGF-β1、TGF-β2、TGF-β3。在TGF-β超家族中，TGF-β亚型的研究最为广泛。根据癌症基因组图谱（TCGA ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

Discussion: Our study indicated that OA might exert anti-renal fibrosis effects through the activation of Sirt1 and the suppression of the TGF-β/Smad3 signaling pathway. The UUO model was established ...