Diabetes. 2006;55(1):1-12. Glucokinase is required for GSIR in the physiological range of 4-8 mmol/l. Glucokinase is needed for amino acid and fatty acid stimulation of insulin release.

It is made of dead, flattened cells called keratinocytes that are shed approximately two weeks after they enter this layer. Keratinocytes produce keratin, a fibrous protein that helps provide ...