Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...

The key to their discovery was finding granzyme K and the memory CD8+ T cells that produce it as important factors causing relapses in stubborn chronic rhinosinusitis with nasal polyps. These could ...

The gut microbiome, or the community of microorganisms residing in the gastrointestinal tract, has emerged as an important ...

Georgia Tech researchers have developed biosensors with advanced sleuthing skills and the technology may revolutionize cancer ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Anirudh Sivakumar (right) and Gabe Kwong led development of new gene-free biosensors for cancer detection. Georgia Tech ...

† Most-abundant zymogen granule proteins. ‡ Different isoforms present in zymogen granules. § Validated by morphological studies after identification by mass spectrometry. As the molecular ...

Furthermore, ELS-containing RA synovia transplanted into SCID mice supported production of ACPA and anti-VCP1/VCP2 antibodies. Analysis of CD4+ and CD8+ T-cell localisation and granzyme B expression ...

新抗原（neoantigens）是癌症治疗领域的“私人定制武器”。它们由肿瘤细胞中的特异性突变生成，仅存在于癌细胞中，而不在正常细胞中表达。这一独特性使新抗原不仅避免了免疫系统对自体组织的耐受性限制，还成为精确识别癌细胞的“信号灯”。

Systematic literature review and meta-analysis informing the EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer ...

A chart showing the explosive expansion in proportion of Granzyme K+ CD8+ T cells in mice across multiple organs as they age. Credit: Laboratory of Single-cell Genomics and Population Dynamics “The ...

肝动脉输注化疗（HAIC）已成为治疗肝细胞癌（HCC）的一种有前景的治疗策略，但对HAIC治疗后的多细胞生态系统缺乏详细的了解。 2024年12月16日，中山大学石明及Kan Anna共同通讯在Advanced Science ...