The key to their discovery was finding granzyme K and the memory CD8+ T cells that produce it as important factors causing relapses in stubborn chronic rhinosinusitis with nasal polyps. These could ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...

研究团队表示，这项研究创新阐明了 CD8+ T 淋巴细胞在鼻息肉复发中的作用，为难治性慢性鼻窦炎鼻息肉的免疫学病理机制提供了新视角。研究定义了补体激活的新途径，揭示了 GZMK 在呼吸道道炎症中作用及机制。