LEAP-012 is a phase 3, double-blinded, active-controlled, multicenter, randomized trial which sought to evaluate lenvatinib (Lenvima) given with pembrolizumab (Keytruda) and transarterial ...

Hepatocellular carcinoma (HCC) represents the most prevalent form of primary liver cancer and has a high mortality rate. Caspase-8 plays a pivotal role in an array of cellular signaling pathways and ...

Precision Pharmacy and Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi, China Introduction: Hepatocellular carcinoma (HCC), the third ...

The HDAC family contains 18 members, and depending on the specificity, HDAC inhibitors can demonstrate antitumour property, and boost ICB therapy efficacy in several tested tumour types including ...

The symbiont's role is thus strongly reminiscent of mitochondria, with the key difference that the endosymbiont derives energy from the respiration of nitrate, not oxygen. Now the researchers from ...

What differentiates Mitolyn from other products on the market is its unique focus on boosting mitochondrial health. Mitochondria are often referred to as the “powerhouses of the cell” because they ...

In the study, the researchers demonstrate that a specific protein plays a key role in the energy production taking place in the cells' energy factory, the mitochondria. And they were surprised to ...

This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is mostly convincing, ...

Houston Community College is one of the largest institutions of higher education in the country with more than 70,000 students each semester, including more international students (nearly 8%) than ...

At variance with the usual HCC, FLC occurs predominantly in young ... of FLC cells having a deeply eosinophilic, finely granular, mitochondrion-rich cytoplasm. All other immunohistological and ...