deletion of an N-terminal JNK structural motif induced Hsp90 and Cdc37 binding, whereas deletion of a C-terminal motif induced only Hsp90 binding 23. In contrast, mutations in the kinase ...

The answer lies in the molecular chaperone heat shock protein 90 (Hsp90), according to a recent report in Current Biology. ...Hsp90 inhibitors could induce a switch from yeast to filamentous ...

热休克蛋白90（HSP90）分子伴侣系统的共伴侣蛋白细胞分裂周期37（CDC37）蛋白在HSP90分子伴侣系统中负责招募待折叠成熟的激酶，随后与HSP90蛋白互作，进而将招募的客户激酶递送给HSP90蛋白。