Researchers from Vera Salus Ricerca Srl and affiliated organizations have reported the discovery and preclinical characterization of novel sigma-1 receptor (S1R) antagonists as potential new analgesic ...

Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.

and mechanical hyperalgesia (increased sensitivity to painful stimuli) induced by TNF (tumor necrosis factor, a signaling protein produced by defense cells that plays a crucial role in regulating ...

and mechanical hyperalgesia (increased sensitivity to painful stimuli) induced by TNF (tumor necrosis factor, a signaling protein produced by defense cells that plays a crucial role in regulating ...

Opioid-induced hyperalgesia (OIH) and allodynia (OIA) are abnormal pain states that result from the class of painkillers called opioids. It's something called a "paradoxical response" in which the ...

Medically reviewed by Erika Prouty, PharmD Substance abuse in the United States is one of the leading health conditions ...