LIN treatment decreased the expression of muscle RING-finger protein-1 (MuRF1) and Atrogin1(MAFbx) in muscle, and the activation of insulin-like growth factor-1 (IGF-1)/protein kinase B (Akt)/forkhead ...

Figure 1: Characterization of MLC/mIgf-1 transgenic mice. Figure 2: MLC/mIgf-1 transgenic mice display pronounced muscle hypertrophy. Figure 3: The hypertrophic action of mIgf-1 is preferentially ...

The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal ...

胰岛素/IGF-1通路对多种动物寿命和衰老速度的影响，在线虫、果蝇和小鼠等多种模式生物中得到验证。多项针对长寿人群的 ...

The Internet Society is a longtime supporter of the IGF. We believe that the opportunities we can create by coming together with diverse stakeholders around common themes can help us combat the ...

16 December 2024 - Amidst a series of global challenges, the 19th United Nations Internet Governance Forum (IGF) opened today in Riyadh, Saudi Arabia under the theme, “Building Our ...

Subcutaneous VRDN-003, a Potential Best-In-Class Anti-IGF-1R, On Track to Report Topline 1H 2026 VRDN-003 is an IGF-1R antibody with the same binding domain as veligrotug and is believed to be the ...

Calls to bridge the digital divide and enable technological access to underserved communities mark the 19th session of the United Nations’ Internet Governance Forum (IGF) held in Riyadh, Saudi Arabia.

VRDN-003 is a half-life-extended anti-IGF-1R antibody with the same binding domain as veligrotug - - Strong cash position of $753 million as of September 30, 2024; provides cash runway into the ...

Doses were individualized based on IGF-1. On the primary endpoint of annualized height velocity and secondary endpoint of change from baseline in height SDS, children treated with TransCon hGH ...

an anti-IGF-1R antibody, in patients with active thyroid eye disease (TED). TED is a rare autoimmune disease in which the body’s own immune system attacks the tissues around and behind the eyes ...