The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal ...

胰岛素/IGF-1通路对多种动物寿命和衰老速度的影响，在线虫、果蝇和小鼠等多种模式生物中得到验证。多项针对长寿人群的 ...