How are induced ... Cell Stem Cell 5, 584–595 (2009). Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Christopher H. Contag and Ahmed A. Zarea explore therapeutic approaches to neurodegenerative diseases using a novel strategy ...

Recent new technologies enabling the genetic modification of human embryonic stem cells and the derivation of patient-specific induced ... of defined transcription factors (Oct4, Klf4, Sox2 ...

A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.

Human induced pluripotent stem cells (hiPSCs) are considered a promising tool in medicine, with the potential to unlock ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various ... suppressor but also plays fundamental roles in aging, metabolism, and stem cell biology. A ...

In vertebrates, pluripotent stem cells only exist during early embryonic stages, driven by specific transcription factors (TFs ... such as in the generation of induced pluripotent stem cells ...

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that ...

This process is commonly reverted in cancer cells (i.e. a soma-to-germline transition) and is intentionally reversed when mammalian somatic cells are reprogrammed into induced Pluripotent ... is ...

This image provides an overview of tissue engineering, highlighting the novel cell sources, tissue architecture techniques, and engineered materials involved in creating functional tissues. It ...