Case 1 suggests that ICA may be a transient marker of a persisting underlying ... indicate inevitable progression to total islet cell destruction and that cessation of immune islet cell ...

Nat Clin Pract Endocrinol Metab. 2006;2(5):240-241. Diabetes occurs when there is an inadequate functional mass of insulin-producing pancreatic β cells. Replacement of β cells by islet ...

Three people with type 1 diabetes who received Vertex Pharma’s islet cell therapy VX-880 have been ... reduction of haemoglobin A1c levels – a marker of blood glucose control – to 7% or ...

Current treatments for T1D, including islet cell transplants ... For Tregs, this means designing CARs that bind only to unique markers on transplanted tissues, ensuring precise immune protection.

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells ... of elevated markers of oxidative ...