Spinal muscular atrophy (SMA) is a genetic, progressive disease that affects the nervous system and muscles. The life expectancy for people with SMA depends on the type of their disease and symptom ...

Double immunofluorescence staining was performed to identify α‐SMA–positive myofibroblasts and CD68‐positive macrophages expressing TRPV4. Immunofluorescence intensity was measured as integrated ...

Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential ...

Due to the progressive nature of spinal muscular atrophy (SMA) — a rare genetic disease — an early diagnosis is critical. People with SMA who receive a timely diagnosis can start treatment immediately ...

The activated HSCs undergo continuous stimulation and proliferation, transdifferentiating into myofibroblasts that secrete large quantities of α-SMA and type I collagen, thereby contributing to ECM ...

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The signals released by these cells activate fibroblasts, which then transform into myofibroblasts and synthesize extracellular matrix (ECM). Chronic injury and inflammation lead to persistent ...

Therefore, a galectin-3 small molecule glycomimetic antagonist is in Phase 2B trials. Galectin-3 may mediate pathogenesis in alveolar epithelial cells (AECs) and myofibroblasts by nucleating a ...

Short-Course Adjuvant Vaginal Cuff Brachytherapy in Early Endometrial Cancer Compared with Standard of Care (SAVE): A Randomized Clinical Trial Pancreatic ductal adenocarcinoma (PDAC) is the third ...

Correspondence to Professor Dr Thomas Gress, Division of Gastroenterology, Endocrinology, Infectiology and Metabolism, University Hospital Giessen and Marburg, Campus Marburg, Philipps University ...