Mitochondrial dysfunction in the brain can disrupt the balance of calcium ions inside and outside neurons, making them fire more readily than they should. Kubota-Sakashita had previously found ...
Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.
They focused on the presence of mitochondria in axons, the long tendril-like appendages that stretch out of neurons and form the necessary connections that allow signals to be transmitted inside ...
"Work is already under way to identify existing licensed drugs that can boost the mitochondria and repair the motor neurons. This will then pave the way to test them in clinical trials." ...
Thus, a loss of dopamine-producing neurons causes a dysbalance in the regulation of movements. "Functionally impaired mitochondria have been recognized to trigger Parkinson's disease already in ...