Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in ...

Now focusing on the PI3K AKT PTEN signaling pathway, activating mutations in PIK3CA and AKT1 and inactivating alterations in PTEN occur in approximately half of luminal breast cancers. In June 2023, ...

The addition of Truqap to standard-of-care therapy improved radiographic progression-free survival in patients with ...

Mutations in PIK3CA, AKT1, and alterations in PTEN occur frequently ... of Truqap “reinforces the important role of the PI3K/AKT pathway in HR-positive breast cancer and the critical need ...

and PTEN-mutated breast cancer. So far, no AKT inhibitors have been brought to market, but several remain in clinical development. Roche's decision to drop the programme comes after AstraZeneca's ...

该研究发现PTEN在创伤性脑损伤（TBI）后持续激活，而神经元PTEN缺失能够持续激活Akt-mTORC1通路，促进长期的神经再生和神经回路重塑。通过这一机制，PTEN缺失有助于改善神经功能，促进轴突修复 ...