The study's primary goal is to assess the therapy’s tolerability, pharmacokinetics and safety in healthy volunteers.

The use of isoenzyme-selective phosphodiesterase (PDE) inhibitors is considered a great opportunity to treat various diseases of the human urogenital tract. PDE inhibitors, in particular the PDE5 ...

A new study reports that mirodenafil, a newly developed oral phosphodiesterase type 5 (PDE5) inhibitor, is an efficacious and safe treatment for erectile dysfunction (ED). Many men with ED ...

The introduction of inhibitors of the cyclic GMP phosphodiesterase (PDE) 5 into clinical urology is mainly the result of the characterization of the physiology of nonvascular and vascular penile ...

Like other prescription medicines, Viagra and its generic form, sildenafil, work best when you take them under the right ...

The cyclic nucleotide phosphodiesterase 4 (PDE4 ... However, none of the PDE4 inhibitors tested so far has reached the market, mainly owing to tolerability issues such as emesis.

The introduction of phosphodiesterase-5 inhibitors (PDE5Is) in the market, such as generic Levitra, has revolutionized the ...

Bhopal: A 27-year-old man died of a cardiac arrest during his stay at a hotel in Gwalior. Police suspect that an overdose of the drug, combined with alcohol, led to the fatal incident. The man, ...

Sildenafil is an ingredient known as a Phosphodiesterase Inhibitor (PDE-5) found in FDA- approved products for the treatment of male erectile dysfunction. According to the FDA, consumption of ...

Additional studies showed a role for the Cgs2 phosphodiesterase that hydrolyzes cAMP to AMP ... We have completed HTSs for PDE4, PDE7, PDE8, and PDE11 inhibitors. The compounds identified in these ...