The study's primary goal is to assess the therapy’s tolerability, pharmacokinetics and safety in healthy volunteers.

The use of isoenzyme-selective phosphodiesterase (PDE) inhibitors is considered a great opportunity to treat various diseases of the human urogenital tract. PDE inhibitors, in particular the PDE5 ...

Like other prescription medicines, Viagra and its generic form, sildenafil, work best when you take them under the right ...

A new study reports that mirodenafil, a newly developed oral phosphodiesterase type 5 (PDE5) inhibitor, is an efficacious and safe treatment for erectile dysfunction (ED). Many men with ED ...

Ensifentrine is a promising supplementary therapeutic option in the management of chronic obstructive pulmonary disease (COPD), according to systematic review and meta-analysis findings published in ...

The introduction of phosphodiesterase-5 inhibitors (PDE5Is) in the market, such as generic Levitra, has revolutionized the ...

While a stuffy nose is a common side effect of oral ED medications, switching from Cialis to shorter-lasting options like ...

Phosphodiesterase-5 inhibitors (sildenafil, vardenafil, tadalafil) enhance nitric oxide production and can cause potentially fatal hypotension when used in combination with nitrates. Nitrates ...

Bhopal: A 27-year-old man died of a cardiac arrest during his stay at a hotel in Gwalior. Police suspect that an overdose of the drug, combined with alcohol, led to the fatal incident. The man, ...

Additional studies showed a role for the Cgs2 phosphodiesterase that hydrolyzes cAMP to AMP ... We have completed HTSs for PDE4, PDE7, PDE8, and PDE11 inhibitors. The compounds identified in these ...

The introduction of inhibitors of the cyclic GMP phosphodiesterase (PDE) 5 into clinical urology is mainly the result of the characterization of the physiology of nonvascular and vascular penile ...