A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are ...

The data demonstrate increased neurotransmitter release and alteration in synapse ultrastructure with higher number of docked vesicles and shorter AZ. The evaluation of presynaptic function of SNX4 is ...

How an electrical signal crosses that synaptic gap is not yet entirely understood, but the basic process seems to go like this: a presynaptic neuron receives a message that it has information to ...

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Many of our academics speak to the media as experts in their field of research. If you are a journalist, please contact the University’s Media and PR Team: ...

“Synaptic vesicles are of paramount importance in brain function and they have been studied ... sphere-like structures that store and release neurotransmitters such as dopamine and serotonin, are ...

From the Harvard Teaching Service, Fifth Surgical Service, the Boston City Hospital. Read at the meeting of the New England Branch of the American Urological Association at Boston, May 17, 1932 ...

We study the molecular and biophysical mechanisms underlying and regulating vesicle trafficking in neurons and in particular in their axons and presynaptic nerve terminals. Our current interest is in ...

In this study, we evaluated the presynaptic targeting of phospho-incompetent (Ser-129A ... Explain the mechanism by which α-synuclein S129site phosphorylation triggers synaptic vesicle recycling. 3.