Tao et al. show that epidermal growth factor receptor and insulin-like growth factor 1 receptor activation enhances thymidine kinase 1 expression through ERK phosphorylation and deubiquitylation ...

Ubiquitylation is the post-translational modification process by which ubiquitin is attached via an isopeptide bond to lysine residues on a protein. Ubiquitylation consists of three steps ...

human chorionic gonadotropin, thymidine phosphorylase ... including tyrosine kinase inhibitors, mammalian target of rapamycin (mTOR) inhibitors (rapamycin), and the monoclonal antibody targeting ...

Buying Modis will add MT1621 to Zogenix’s pipeline, an investigational drug for thymidine kinase 2 deficiency (TK2d), an inherited mitochondrial DNA depletion disorder that affects children and ...

Presented updated clinical and biomarker activity data at the IOVC in October 2024. Investigators reported ongoing improved ...

1 Department of Gastroenterology and Hepatology ... One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in ...