Certain metabolic intermediates (e.g., acetyl-CoA) are linked with alteration of cellular epigenome. In mammalian cells, nuclear acetyl-CoA production is dependent on two enzymes, namely ...

Cells prefer ACLY but, in the event of problems, ACSS2 picks up the slack to ensure a continual supply of acetyl-CoA. Although this type of "metabolic flexibility" has been observed in cancer ...

the metabolic enzyme determined the location of acetyl-CoA, (3) the location of acetyl-CoA determined what gene-modifying histone acetyltransferases were activated, and (4) those histone ...