The tension elevation activated the mechanosensitive ion channel Tmem63b and triggered Ca 2+ influx, leading to actomyosin activation at the rear of the cell. Blockade of this signaling pathway ...

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More information: Jianmin Yin et al, Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1, Nature Communications (2024).

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team has uncovered new mechanisms in blood vessel formation.

The formation of blood vessels is a complex process involving the interplay of proteins and mechanic forces. In two studies, a research team at the Biozentrum of the University of Basel ...

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Vascular Biology Program, Boston Children’s Hospital, MA (J.E.I., C.P., R.H.B.). Department of Surgery, Harvard Medical School, Boston, MA (J.E.I., C.P., R.H.B ...

Professor Chris Bakal’s group uses genomic approaches and computational modelling to understand how complex biochemical signalling networks are ‘rewired’ during the development of cancer. Our goal is ...