eIF4F由三个亚基组成：负责直接结合帽端的eIF4E、具有解旋酶功能的eIF4A以及作为支架蛋白的eIF4G。这些亚基共同协作，帮助将mRNA招募到核糖体预起始 ...

此外，体液标志物可以用于 监测AD临床试验的疗效 ，如在 仑卡奈单抗的Ⅲ期临床试验 中， 血浆p-tau181、Aβ42/40比值、GFAP 被用作关键次要终点的评估方法，用于监测仑卡奈单抗的疗效。

Seasoned advisory group including RNA, translation and commercialisation luminaries.

Mounting an immune response is a metabolically costly endeavour and cannot operate well under conditions of energy deficit. Energy surplus (for example, in individuals that are obese or suffer ...

The mechanisms by which dietary fructose promotes tumour progression have remained poorly understood. A recent study published in Nature reveals that dietary fructose is metabolized in the liver ...

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., P.O. Box B, Frederick 21702, Maryland, United States ...

Introduction: Many breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to the therapeutics targeting this pathway is a frequent occurrence. Therapeutics ...

Medicines Discovery Institute, School of Biosciences, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U.K.