Chromosome 5q deletion syndrome - Wikipedia
Chromosome 5q deletion syndrome is an acquired, hematological disorder characterized by loss of part of the long arm (q arm, band 5q33.1) of human chromosome 5 in bone marrow myelocyte cells. This chromosome abnormality is most commonly associated with …
5q minus syndrome - MedlinePlus
5q minus (5q-) syndrome is a type of bone marrow disorder called myelodysplastic syndrome (MDS). Explore symptoms, inheritance, genetics of this condition.
The 5q- syndrome - PubMed
The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytogenetic, molecular, and prognostic features. It is defined as a myelodysplastic syndrome with a medullary blast count <5% and an isolated interstitial deletion of the long arm of chromosome 5, including bands q31-q33.
Advances in the 5q− syndrome - American Society of Hematology
2010年12月23日 · The 5q− syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The significant progress made during recent years has been based on the determination of the commonly deleted region and the demonstration of haploinsufficiency for the ribosomal gene RPS14. The functional screening of all ...
5號染色體長臂缺失症候群 - 维基百科，自由的百科全书
5號染色體長臂缺失症候群 （Chromosome 5q deletion syndrome 、5q症候群、5號長臂 染色體單體症 (monosomy)、5號染色體長臂缺失綜合症）是一種 後天性 血液疾病，特徵是人類 5號染色體 「長臂」（q arm, band 5q31.1）的一部分缺失。 這種染色體異常最常見伴隨著 骨髓增生异常综合征 （MDS）而產生。 它不與“5號長臂部分 染色體三倍體症 （partial trisomy 5q）”等同，雖然這兩種病症的產生都在同一個系列裡可以觀察的到。 [1] 此種症狀不能和 猫叫综合症 混為一談， …
Recent Advances in the 5q- Syndrome - PMC - PubMed Central …
The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this disorder have a deletion of chromosome 5q [del(5q)] as the sole karyotypic abnormality. Several genes mapping to the commonly deleted region of the 5q- syndrome have been implicated in disease pathogenesis in recent years.
5q- Syndrome - an overview | ScienceDirect Topics
The 5q- syndrome is defined by the World Health Organization (WHO) as a specific type of MDS with the diagnosis limited to cases with isolated 5q deletions with less than 5% of blasts [1]. The 5q deletion, either isolated or in association with additional abnormalities or complex karyotypes is the most common cytogenetic abnormality in MDS and ...
5q- Syndrome - an overview | ScienceDirect Topics
Clinically, 5q− syndrome is characterized by a predominant anemia with preservation or even elevation of platelet counts, striking pathologic feature is the presence of mononuclear micromegakaryocytes identified in the bone marrow biopsy (Fig. 60.5A–C) and an indolent course with progression to AML in fewer than 25% of cases. 343,344 For ...
The 5q- syndrome: biology and treatment - PubMed
The 5q- syndrome is a myelodsyplastic syndrome (MDS) characterized by symptomatic anemia and an indolent natural history with low transformation potential. Our understanding of the molecular pathogenesis of this disease has advanced considerably, paralleled by the delineation of the relevant targets …
The 5q– Syndrome - ScienceDirect
1994年11月15日 · THE 5q– SYNDROME was first described by Van den Berghe et al 1 in 1974 in three patients with refractory anemia and an interstitial deletion of the long arm of chromosome 5. This review discusses the clinical features of the 5q– syndrome and the role of candidate genes in the pathogenesis of the syndrome, taking into account recent evidence ...