Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk ...
It is the purpose of this review to describe the current state of knowledge about the role of peroxisomes in fatty acid oxidation, the transport of metabolites across the peroxisomal membrane, its functional interaction with other subcellular organelles and the disorders of peroxisomal fatty acid β-oxidation identified so far in humans.
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids ...
2021年12月13日 · Here we report a sensing mechanism for cellular FAs based on peroxisomal degradation of FAs and coupled with reactive oxygen species (ROS) production, which in turn regulates FA release by...
Peroxisomal β-oxidation—A metabolic pathway with multiple functions
2006年12月1日 · Peroxisomal β-oxidation in fungi, such as Saccharomyces cerevisiae, is primarily devoted to the degradation of (often extracellular) fatty acids for the subsequent use of acetyl-CoA as a carbon and energy source for growth, although β-oxidation was also shown to be involved in the endogenous turnover of intermediates leaking out of the fatty ...
Peroxisomal β-oxidation enzyme, DECR2, regulates lipid ... - Nature
2024年1月12日 · Peroxisomes are central metabolic organelles that have key roles in fatty acid homoeostasis. As prostate cancer (PCa) is particularly reliant on fatty acid metabolism, we explored the...
Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling
2014年3月4日 · The main metabolic functions of peroxisomes in mammalian cells include β-oxidation of very long chain fatty acids, α-oxidation of branched chain fatty acids, synthesis of bile acids and ether-linked phospholipids, and removal of reactive oxygen species.
Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling
2014年3月4日 · Beevers and colleagues implicated peroxisomes in lipid metabolism by demonstrating that enzymes involved in fatty acid oxidation are colocalized in plant peroxisome-like organelles called glyoxysomes, which are capable of converting fatty acids to metabolic intermediates for carbohydrate synthesis (Cooper and Beevers, 1969).
Peroxisomes as cellular adaptors to metabolic and ... - Cell Press
2021年3月2日 · In mammalian cells, fatty acids can be catabolized via β-oxidation in mitochondria and peroxisomes. VLCFAs (≥22 carbons) are exclusively oxidized in peroxisomes . This process requires the fatty acid to be first activated to an acyl-CoA by acyl-CoA synthetase (ACSL) in the presence of ATP .
Fatty Acid Metabolism in Peroxisomes and Related Disorders
Main metabolic pathways of fatty acids in peroxisomes. The β-oxidation pathways of saturated and unsaturated fatty acyl-CoAs are indicated by black arrows, those of pristanoyl-CoA and di/trihidroxycholestanoyl (D/THCA)-CoA by black dashed arrows, and those of dicarboxylyl-CoAs by black dotted arrows.
Peroxisomal beta-oxidation--a metabolic pathway with multiple ... - PubMed
Fatty acid degradation in most organisms occurs primarily via the beta-oxidation cycle. In mammals, beta-oxidation occurs in both mitochondria and peroxisomes, whereas plants and most fungi harbor the beta-oxidation cycle only in the peroxisomes.
Peroxisomes can oxidize medium- and long-chain fatty acids ... - PubMed
Peroxisomes are essential organelles for the specialized oxidation of a wide variety of fatty acids, but they are also able to degrade fatty acids that are typically handled by mitochondria. Using a combination of pharmacological inhibition and clustered regularly …