Salinomycin - Wikipedia
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Antibacterial activity.
Salinomycin, a promising anticancer stem cell agent
2024年4月18日 · Salinomycin is an antibiotic and widely used in veterinary medicine (since the 1970s) as a feed additive to control coccidiosis in poultry, the single-cell parasitic disease of the intestinal tract, and also as a non-hormonal growth promoter.
Salinomycin as a Drug for Targeting Human Cancer Stem Cells
2012年11月21日 · Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/ β -catenin signaling pathway, and other CSC pathways.
Salinomycin: A new paradigm in cancer therapy - PubMed
The potential of salinomycin to eliminate both cancer stem cells and therapy-resistant cancer cells may characterize the compound as a novel and an efficient chemotherapeutic drug. Keywords: Salinomycin; cancer; cancer stem cells; multidrug resistance.
Salinomycin, as an autophagy modulator-- a new avenue to …
2018年2月13日 · Salinomycin. Autophagy regulator. Preference for cancer stem cells (CSCs) or cancer. Anticancer agent. Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects.
Anticancer Mechanisms of Salinomycin in Breast Cancer and Its …
2021年7月26日 · Salinomycin, a monocarboxylic polyether antibiotic isolated from Streptomyces albus, can precisely kill cancer stem cells (CSCs), particularly BCSCs, by various mechanisms, including apoptosis, autophagy, and necrosis.
Salinomycin and its derivatives – A new class of multiple-targeted ...
2019年8月15日 · Salinomycin (SAL) exhibits antibacterial, antifungal, antiviral, antiparasitic and anticancer activity. SAL combines a broad spectrum of bioactivity with high selectivity of action, proving its significant therapeutic potential.
Salinomycin kills cancer stem cells by sequestering iron in
2017年5月16日 · Here, we provide evidence that a synthetic derivative of salinomycin, which we named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by...
Salinomycin - an overview | ScienceDirect Topics
Salinomycin is a monocarboxylic polyether antibiotic isolated from the bacterial strain Streptomyces albus. It is a broad-spectrum antibacterial agent against gram-positive bacteria, fungi and parasites [93, 94]. Salinomycin is a selective agent for cancer stem cells (CSCs) through an elusive mechanism.
Salinomycin kills cancer stem cells by sequestering iron in ... - PubMed
Here, we provide evidence that a synthetic derivative of salinomycin, which we named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by accumulating and sequestering iron in lysosomes.
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