CD74 - Wikipedia
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene.
CD74 Gene - GeneCards | HG2A Protein | HG2A Antibody
2024年12月9日 · CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Macular Keratitis and Mucinous Lung Adenocarcinoma. Among its related pathways are Innate Immune System and Immune response Antigen presentation by MHC class II.
The biological function and significance of CD74 in immune ... - PubMed
CD74 plays important roles in many inflammatory diseases, such as liver fibrosis, type I diabetes, systemic lupus erythematosus, and Alzheimer disease. In this study, we will focus on the immunological functions of CD74 molecules and its roles in immune-relevant disorders.
The biological function and significance of CD74 in immune diseases
2016年10月17日 · CD74 plays important roles in many inflammatory diseases, such as liver fibrosis, type I diabetes, systemic lupus erythematosus, and Alzheimer disease. In this study, we will focus on the immunological functions of CD74 molecules and its …
CD74 is a novel transcription regulator - PNAS
2016年12月28日 · CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74–ICD), which regulates cell survival.
CD74 is a novel transcription regulator - PMC
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74–ICD), which regulates cell survival.
The multifaceted roles of the invariant chain CD74 - ScienceDirect
2016年6月1日 · CD74 is a receptor of the cytokine macrophage migration inhibitory factor (MIF). Invariant chain is up-regulated in several types of cancer. The invariant chain (CD74) is well known for its essential role in antigen presentation by mediating assembly and subcellular trafficking of the MHCII complex.
CD74 as a regulator of transcription in normal B cells - Cell Press
2022年11月1日 · CD74 is receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF binding to CD74 induces a signaling cascade resulting in the release of its cytosolic intracellular domain (CD74-ICD) that serves as a transcriptional regulator in chronic lymphocytic leukemia (CLL) cells.
CD74 is a potential biomarker predicting the response to immune ...
CD74 is an essential membrane protein that associates with class II major histocompatibility complex (MHC II) and is an important chaperone that regulates antigen presentation for immune response.
CD74 as a prognostic and M1 macrophage infiltration marker in a ...
2024年4月7日 · Elevated CD74 expression was associated with reduced levels of mismatch-repair genes and homologous repair gene signatures in over 10 tumor types. Multiple fluorescence staining and bulk, spatial, single-cell transcriptional analyses indicated its potential as a marker for M1 macrophage infiltration in pan-cancer.