High Expression of CDCA7 in the Prognosis of Glioma and Its ...
2023年7月6日 · The P53 signaling pathway, cell cycle pathway, nucleotide excision repair pathway, and homologous recombination pathway may be the main pathways of CDCA7 in regulating glioma. In addition, we also revealed the potential role of CDCA7 in regulating ferroptosis by interacting with several ferroptosis suppressor genes in gliomas and identified ...
High Expression of CDCA7 in the Prognosis of Glioma and Its ...
2023年7月6日 · CDCA7 may affect ferroptosis by interacting with genes in the cell cycle pathway and P53 pathway. The increase in CDCA7 was positively correlated with multiple ferroptosis suppressor genes and genes involved in tumor-infiltrating immune cells and immune checkpoint molecules in glioma.
Role of cell division cycle-associated proteins in regulating cell ...
2024年9月1日 · CDCA7 is distributed in the nucleus and cytoplasm of cells and concentrated in human intestinal and lymphoid tissues. CDCA7, also known as ICF3 (Immunodeficiency-centromeric instability-facial anomalies), can form chromatin-associated complexes with HELLS and promote nucleosome remodeling.
CDCA7 is a critical mediator of lymphomagenesis that selectively ...
Here we show that CDCA7 was one of the most significantly up-regulated genes, that its encoded protein is overexpressed in lymphoid tumors, and that its silencing greatly impairs lymphomagenesis without inhibiting the proliferation of normal cells. Detailed Methods can be found in the Online Supplementary Appendix.
High expression of CDCA7 predicts poor prognosis for clear ... - PubMed
2021年3月1日 · The prognostic nomogram integrating CDCA7 expression level and clinicopathologic variables was constructed to predict 1-, 3- and 5-year OS. GSEA indicated that high CDCA7 expression was related to the apoptosis pathway, cell cycle pathway, JAK-STAT pathway, NOD like receptor pathway, P53 pathway, T …
High expression of CDCA7 predicts poor prognosis for clear cell …
2021年3月1日 · Univariate and multivariate Cox regression analyses identified CDCA7 as an independent prognostic factor (both P < 0.05). The prognostic nomogram integrating CDCA7 expression level and clinicopathologic variables was constructed to predict 1-, 3- and 5-year OS.
p53 gain‐of‐function mutations increase Cdc7‐dependent …
2017年9月8日 · Here, we show that enhanced Cdc7‐dependent replication initiation enables mutant p53 to confer oncogenic phenotypes. We demonstrate that mutant p53 cooperates with the oncogenic transcription factor Myb in vivo and transactivates Cdc7 in cancer cells.
CDCA7-associated global aberrant DNA hypomethylation
2024年2月9日 · Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact of DNA methylation loss on transcription has not been investigated. Here, we show that CDCA7 is critical for maintaining global DNA methylation levels across multiple tissues in vivo.
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon ...
Here we report a novel mechanism in which p53 induces G1 checkpoint and cell cycle arrest by downregulating CDC7 kinase in response to genotoxic stress. We demonstrate that p53 controls CDC7 stability post-transcriptionally via miR-192/215 and post …
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon ...
Here we report a novel mechanism in which p53 induces G1 checkpoint and cell cycle arrest by downregulating CDC7 kinase in response to genotoxic stress. We demonstrate that p53 controls CDC7 stability post-transcriptionally via miR-192/215 and post …