Nucleotide and nucleoside-based drugs: past, present, and future
Nucleotide and nucleoside-based analogue drugs are widely used for the treatment of both acute and chronic viral infections. These drugs inhibit viral replication due to one or more distinct mechanisms. It modifies the virus's genetic structure by …
Current status and trends in small nucleic acid drug development ...
2024年9月1日 · Small nucleic acid drugs, or oligonucleotide drugs, are short strands of nucleic acids composed of several dozen nucleotide tandems. They share the commonality of being composed of short nucleic acid sequences designed to interact with specific target molecules within cellular pathways.
The current landscape of nucleic acid therapeutics - Nature
2021年5月31日 · Here, we review four platform technologies that have enabled the clinical translation of nucleic acid therapeutics: antisense oligonucleotides, ligand-modified small interfering RNA conjugates,...
Nucleic Acid Drugs—Current Status, Issues, and Expectations for ...
Nucleic acid drugs provide novel therapeutic modalities with characteristics that differ from those of small molecules and antibodies. In this review, I focus on the various mechanisms through which nucleic acid drugs act on, the status of their clinical development, and discuss several hurdles that need to be surmounted.
Nucleic acid drugs: recent progress and future perspectives
2024年11月29日 · Nucleic acid drugs (NADs) are a new generation of gene-editing modalities characterized by their high efficiency and rapid development, which have become an active research topic in new drug ...
Editorial: Recent trends and spotlight on nucleotide-based drugs: …
Nucleotide/nucleoside-based drugs are already very well explored, with clinically approved candidates as antiviral, anti-cancer, anti-bacterial and anti-rheumatoid etc (Garner, 2021). Oligonucleotide therapy is relative recent and promising, comprising of Antisense Oligonucleotides (ASOs), Small Interfering RNAs (siRNAs), Short Hairpin RNAs ...
Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to
2021年2月9日 · Nucleoside and nucleotide antiviral agents are an important drug class with broad-spectrum antiviral activities to treat current and emerging infectious diseases worldwide, thereby encouraging future development of novel nucleos(t)ide analogues.
Nucleosides, Nucleotides and Nucleic Acids as ... - ACS …
2021年11月9日 · This review focuses on the chem. synthesis and biol. of anticancer nucleoside, nucleotide, and base analogs that are FDA-approved and in clin. development since 2000. The authors highlight the cellular biol. and clin. biol. of analogs, drug resistance mechanisms, and compd. specificity towards different cancer types.
Nucleotide and nucleoside-based drugs: past, present, and future
2022年12月1日 · Nucleotide and nucleoside-based analogue drugs are widely used for the treatment of both acute and chronic viral infections. These drugs inhibit viral replication due to one or more distinct mechanisms. It modifies the virus's genetic structure by reducing viral capacity in every replication cycle.
Cell and Tissue Specific Metabolism of Nucleoside and Nucleotide Drugs ...
Many clinically used antiviral drugs are nucleoside or nucleotide analog drugs, which have a unique mechanism of action that requires intracellular phosphorylation. This dependence on intracellular activation presents novel challenges for the discovery and development of nucleoside/nucleotide analog …