Autophagy protein 5 - Wikipedia
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the …
自噬信号通路 | Cell Signaling Technology
Atg 基因通过 Atg12-Atg5 以及 LC3-II (Atg8-II) 复合体，控制自噬体的形成。 Atg12 通过一个需要 Atg7 和 Atg10（分别对应 E1 和 E2 样酶）参与的泛素样反应，结合到 Atg5。
自噬相关蛋白ATG5调控细胞自噬和凋亡的研究进展 - 中华医学杂志
目前认为，ATG5和LC3－Ⅱ在自噬体和自噬小泡形成中起重要作用，ATG5参与自噬体的起始、成核、延伸、闭合等阶段，而LC3－Ⅱ是自噬体发生和发展过程中唯一留存在自噬体双层膜上的 …
自噬标志物—LC3检测要点 - 知乎 - 知乎专栏
微管相关蛋白 1轻链3 (MAP1LC3)，是Atg8在哺乳动物中的 同源物。 LC3/Atg8 被具有蛋白内切酶活性的Atg4在羧基端剪切，生成胞浆型 LC3-I。 在自噬形成时，胞浆型LC3-I通过Atg7 和 …
Autophagy regulator ATG5 preserves cerebellar function by
1 天前 · Two ubiquitin-like conjugating systems, ATG12–ATG5–ATG16L1 and LC3-I/LC3-II, are essential for the elongation and closure of the autophagosome membrane 2, and the absence …
Frontiers | Exploring the Role of Autophagy-Related Gene 5 (ATG5 ...
2018年10月16日 · ATG5, via its lipidation of LC3, plays a key role in the two conjugation systems of the LAP pathway (Figure 1). It is speculated that LC3 lipidation might alter the activity of …
LC3-associated endocytosis and the functions of Rubicon and …
2022年10月26日 · In canonical autophagy, ATG12-ATG5-ATG16L1 complexes exert E3 ligase activity that catalyzes LC3 recruitment to double-membrane phagophores and activates the E2 …
Molecular mechanisms and physiological roles of Atg5/Atg7 …
Conventional autophagy requires Atg5 and Atg7, is associated with LC3 modification, and is thought to originate from the ER membrane. In contrast, alternative autophagy occurs …
STING directly activates autophagy to tune the innate immune …
2018年12月19日 · STING induces non-canonical autophagy that is dependent on ATG5, whereas other autophagy regulators such as Beclin1, Atg9a, ULK1, and p62 are dispensable. LIR …
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation ...
Here we set out to identify the role of the conjugation between ATG12 and ATG5 in LC3 lipidation. We demonstrate that the native conjugation moeity is crucial for E3 activity using artifical …