Caspase - Wikipedia
Structure of caspase-1 (CASP1), originally called interleukin-1 beta-converting enzyme (ICE), the first human caspase to be identified. [1] Caspases (c ysteine- asp artic prote ases, c ysteine asp art ases or c ysteine-dependent asp artate-directed prote ases) are a family of protease enzymes playing essential roles in programmed cell death.
The protein structures that shape caspase activity, specificity ...
This review focuses on caspase structure/function studies over the last 10 years, and sets them in the context of current concepts of the biological role and regulation of cell death and pro-inflammatory cytokine activation.
Caspase-3: Structure, function, and biotechnological aspects
Caspase-3, a cysteine-aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until it …
Caspases and their substrates | Cell Death & Differentiation - Nature
2017年5月12日 · Caspases are a family of cysteine proteases whose functions are inextricably linked with the process of programmed cell death, or apoptosis, in all metazoans, including C. elegans, Drosophila,...
Caspases and their substrates - PMC - PubMed Central (PMC)
The human caspase family is divided into three main groups, primarily based on sequence similarity and biological function. 15 Group I comprises the inflammatory caspases-1, -4, and -5 (caspase-11 in mouse), based on the commonalities of having a long caspase-recruitment domain and a preference for a large aromatic or hydrophobic residue at the ...
Caspases segregate into two major phylogenic sub-families (ICE, CED-3). Based on their proteolytic specificities (see Figure 3), caspases further divide into three groups: group I enzymes (blue)...
A Review on Caspases: Key Regulators of Biological Activities and ...
In mammals, the caspases are mainly divided into three functional groups based on their known roles in apoptosis: (1) initiator caspases, (2) effector caspases/executioner caspases, and (3) inflammatory caspases. Table 2 summarizes the properties and biological roles of …
Caspase structure, proteolytic substrates, and function during ...
Caspases play an essential role during apoptotic cell death. These enzymes define a new class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct mammalian family members.
RCSB PDB - 2H51: Crystal structure of human caspase-1 (Glu390 …
2006年5月25日 · Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bound by a synthetic allosteric ligand at the dimer interface approximately 15 A from the active site.
Mammalian caspases: structure, activation, substrates, and functions ...
Caspases are synthesized as relatively inactive zymogens that become activated by scaffold-mediated transactivation or by cleavage via upstream proteases in an intracellular cascade.