Blood pressure targets for older adults with high blood pressure
When comparing a higher BP target, in the range of < 150 to 160/95 to 105 mmHg, to a lower BP target of 140/90 or lower, over two to four years of follow-up, there is high-certainty evidence that the lower BP target reduces stroke, and moderate-certainty evidence that the lower BP target likely reduces serious cardiovascular events.
Oocyte activation for women following intracytoplasmic sperm …
We are uncertain about the effect of AOA on the live birth and miscarriage rates in women undergoing ART ICSI. In the subpopulation of those who have had a previous history of low or no fertilization, AOA may result in an increase in the live birth rate when compared to conventional ICSI without AOA, while making little or no difference to the miscarriage rate.
How accurate are cognitive assessment tools, that are ... - Cochrane
Dementia is a chronic and progressive clinical syndrome that can present with a range of cognitive and behavioural symptoms. Global prevalence is projected to increase due to ageing populations, particularly in resource-limited settings, with …
What were the unintended consequences of school-based
Why is this question important? During the COVID-19 pandemic, different measures were implemented in schools to help stop the virus spreading. These measures included changes to school rules or actions with the following goals.
Does testosterone work in men who have problems with erections?
Clinical practice guidelines recommend testosterone replacement therapy (TRT) for men with sexual dysfunction and testosterone deficiency. However, TRT is commonly promoted in men without testosterone deficiency and existing trials often do not clearly report participants' testosterone levels or testosterone-related symptoms.
Medicines to treat people with vascular dementia and other …
We included eight trials (4373 participants) in the review. Three trials studied donepezil 5 mg or 10 mg daily (n= 2193); three trials studied rivastigmine at a maximum daily dose of 3 to 12 mg (n= 800); and two trials studied galantamine at a maximum daily dose of 16 to 24 mg (n= 1380).
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Stopping or continuing anti-dementia drugs in patients with
This review suggests that discontinuing cholinesterase inhibitors may result in worse cognitive, neuropsychiatric and functional status than continuing treatment, although this is supported by limited evidence, almost all of low or very low certainty.
Steroids for the common cold - Cochrane
Review question. We reviewed the evidence for using steroid medications to improve symptoms in patients who have a common cold. Background. Common colds are experienced by over half a billion patients annually in the USA alone and result in significant loss of productivity.
Oral steroids for shoulder pain (adhesive capsulitis) - Cochrane
Available data from two placebo-controlled trials and one no-treatment controlled trial provides "Silver" level evidence (www.cochranemsk.org) that oral steroids provides significant short-term benefits in pain, range of movement of the shoulder and function in adhesive capsulitis but the effect may not be maintained beyond six weeks.