AMPK: Sensing Glucose as well as Cellular Energy Status
2018年2月6日 · Mammalian AMPK is known to be activated by falling cellular energy status, signaled by rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs but also discuss new studies suggesting that AMPK is able to sense glucose availability independently of changes in adenine nuc …
Negative regulation of AMPK signaling by high glucose via E3 ... - PubMed
2021年2月4日 · Here, we demonstrate that high glucose represses AMPK signaling via MG53 (also called TRIM72) E3-ubiquitin-ligase-mediated AMPKα degradation and deactivation. Specifically, high-glucose-stimulated reactive oxygen species (ROS) signals AKT to phosphorylate AMPKα at S485/491, which facilitates the …
AMPK: Sensing Glucose as well as Cellular Energy Status - Cell Press
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs but also discuss new studies suggesting that AMPK is able to sense glucose availability independently of changes in adenine nucleotides.
林圣彩教授课题组在Nature杂志上发文阐释AMPK响应葡萄糖的机 …
7月19日，厦门大学林圣彩教授课题组在国际顶级学术杂志《自然》上发表了题为“Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK”—“果糖1,6-二磷酸和醛缩酶介导AMPK感知葡萄糖”的研究性论文，揭示了机体感受葡萄糖水平并调节代谢模式的机制。
AMPK: mechanisms of cellular energy sensing and restoration of ...
AMPK promotes glucose uptake by phosphorylating TBC1D1 (TBC domain family, member 1) and TXNIP (thioredoxin-interacting protein), which control the translocation and cell-surface levels of glucose transporters GLUT4 and GLUT1, respectively (Hardie, 2013; Wu et al., 2013), though through distinct mechanisms.
AMP-activated protein kinase signaling in metabolic regulation
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and lipid oxidation to produce energy, while turning off energy-consuming processes including glucose and lipid production to restore energy balance.
AMPK: Mechanisms of Cellular Energy Sensing and Restoration …
2017年6月15日 · AMPK promotes glucose uptake by phosphorylating TBC1D1 (TBC domain family, member 1) and TXNIP (thioredoxin-interacting protein), which control the translocation and cell-surface levels of glucose transporters GLUT4 and GLUT1, respectively (Hardie, 2013, Wu et al., 2013), albeit through distinct mechanisms.
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs but also discuss new studies suggest-ing that AMPK is able to sense glucose availability independently of changes in adenine nucleotides.
AMPK signaling in diabetes mellitus, insulin resistance and diabetic ...
2022年2月1日 · AMPK signaling can significantly enhance glucose uptake in muscle and other cells to reduce serum glucose levels via upregulating GLUT1 and GLUT4 as its transporters. Furthermore, AMPK signaling is beneficial in enhancing glucose metabolism in cells via inducing SIRT1 and promoting PGC-1α expression.
AMPK: guardian of metabolism and mitochondrial homeostasis
2017年10月4日 · This study discovers a provocative new AMP-independent mechanism for glucose sensing by AMPK that involves a super-complex of LKB1, axin, AMPK, the LAMTOR–Ragulator complex and the glycolytic...