rs1042713 - SNPedia
2021年1月18日 · rs1042713, also known as Arg16, G16R, and 16Arg>Gly, is a SNP in the adrenergic, beta-2-, surface receptor ADRB2 gene. The rs1042713(G) allele encodes the G/glycine form that is the more common one in most populations, while rs1042713(A) encodes the R/arginine residue at this position of the ADRB2 protein.
Childhood asthma exacerbations and the Arg16 β2
2016年7月1日 · We sought to undertake a meta-analysis to test the hypothesis that there is an interaction between the A allele of rs1042713 (Arg16 amino acid) and long-acting β-agonist (LABA) exposure for asthma exacerbations in children.
Childhood asthma exacerbations and the Arg-16 beta2 receptor ...
To undertake a meta-analysis to test the hypothesis that there is an interaction between the A allele of rs1042713 (Arg16 amino acid) and long acting beta agonist (LABA) exposure for asthma exacerbations in children. Children with diagnosed asthma were recruited in five populations (BREATHE, GALA II, PACMAN, PAGES and PASS).
Arg16 ADRB2 genotype increases the risk of asthma exacerbation …
Background: Current evidence suggests that asthma patients with the ADRB2 Arg16 genotype have a poorer response to long-acting β2-agonists (LABA), but the results remain inconsistent. Aim: This study assessed the association between Arg16 variants and treatment outcome in children treated with inhaled corticosteroids (ICS) and LABA.
Childhood asthma exacerbations and the Arg16 β
Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting beta2-agonists: results of the PACMAN cohort
Arg16Gly polymorphism of the β2-adrenergic receptor is …
In humans, subjects homozygous for arginine (ArgArg) at codon 16 of the β 2 -adrenergic receptor (β 2 AR) have been shown to have greater agonist-mediated desensitization than subjects homozygous for glycine (GlyGly).
Childhood asthma exacerbations and the Arg16 β2-receptor
Objectives: We sought to undertake a meta-analysis to test the hypothesis that there is an interaction between the A allele of rs1042713 (Arg16 amino acid) and long-acting β-agonist (LABA) exposure for asthma exacerbations in children.
The Arg16/Gly β2-adrenergic receptor polymorphism is associated …
2004年2月13日 · To test the hypothesis that the Arg16/Gly polymorphism is associated with differences in acute pressor responses to sympathoexcitation, we measured mean arterial pressure (MAP, Finapres) and heart rate (HR, ECG) during mental stress (MS), cold pressor test (CPT), and handgrip (HG) to fatigue in 31 healthy, nonobese, normotensive adults (mean ...
ADRB2 Arg16Gly Polymorphism, Lung Function, and Mortality
2007年3月14日 · Growing evidence suggests that the Arg16Arg genotype of the beta-2 adrenergic receptor gene may be associated with adverse effects of beta-agonist therapy. We sought to examine the association of beta-agonist use and the Arg16Gly polymorphism with lung function and mortality among participants in the Atherosclerosis Risk in Communities study.
β2-Adrenergic Receptor Arg16/Arg16 Genotype Is Associated …
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).