Azacitidine - Wikipedia
Azacitidine, sold under the brand name Vidaza among others, is a medication used for the treatment of myelodysplastic syndrome, myeloid leukemia, [5][6] and juvenile myelomonocytic leukemia. [4][9] It is a chemical analog of cytidine, a nucleoside in DNA and RNA. [medical citation needed] Azacitidine and its deoxy derivative, decitabine (also kn...
阿扎胞苷 - 维基百科，自由的百科全书
阿扎胞苷 （INN：Azacitidine），有时也称为 5-阿扎胞苷 （5-Azacitidine），商品名维达莎或委丹扎（Vidaza），是一种 胞苷 （组成 DNA 与 RNA 的 核苷 之一） 类似物，由 捷克斯洛伐克 学者 弗朗蒂斯克·索姆 （František Šorm）于20世纪60年代首先合成用于 肿瘤 化疗 [4]，目前主要用于治疗 骨髓增生异常综合征 [5]。 阿扎胞苷目前也是一种在生物医学研究中常用的 DNA甲基化 抑制剂 [6][7]。 阿扎胞苷有一种脱氧衍生物 地西他滨 [8]。 阿扎胞苷是一种 胞苷 类似物。 在低剂 …
阿扎胞苷(Azacitidine) - 药物靶点：DNMT1_在研适应症：幼年型骨 …
Azacitidine is in a class of medications called demethylation agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells. Giving regorafenib in combination with venetoclax and azacitidine may be safe, tolerable and/or effective in treating patients with relapsed or refractory AML.
5-氮杂胞嘧啶核苷 - 百度百科
5-氮杂胞嘧啶核苷，又名5-氮胞苷、 阿扎胞苷 ，是一种有机化合物，化学式为C8H12N4O5，主要用作抗肿瘤药，临床上用于治疗乳腺癌、肠癌、黑色素瘤、急性粒细胞性白血病等。 2017年10月27日，世界卫生组织国际癌症研究机构公布的致癌物清单初步整理参考， 阿扎胞苷在2A类致癌物清单中。 [2] 主要用作抗肿瘤药，临床上用于治疗乳腺癌、肠癌、黑色素瘤、急性粒细胞性白血病等。 S22：Do not breathe dust. 不要吸入粉尘。 S36/37/39：Wear suitable protective …
Azacitidine 300 Mg Tablet - Uses, Side Effects, and More - WebMD
Azacitidine is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.This form of azacitidine should not be used in place of the form given by injection. Take this...
5-Azacytidine：一种具有多重功能的抗肿瘤药物 - 百度
2023年12月12日 · 5-Azacytidine是一种具有多重功能的抗肿瘤药物，具有特异型抑制 DNA 甲基化的作用，可以逆转表观遗传变化并诱导细胞自噬 (autophagy)。 虽然其不良反应需要关注，但在正确的使用下，它可以为肿瘤患者提供一种有效的治疗选择。
Azacitidine Uses, Side Effects & Warnings - Drugs.com
2024年10月9日 · Azacitidine oral is used to treat acute myeloid leukemia in people who are in remission but cannot finish other treatments for this condition. Azacitidine injection is used to treat certain types of bone marrow cancers and blood cell disorders. Azacitidine may also be used for purposes not listed in this medication guide.
5-Azacytidine (Azacitidine，5-氮杂胞苷) - 仅供科研 | DNMT抑制 …
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse …
Azacitidine - Pharmaceutical Drugs - NCBI Bookshelf
Azacitidine is a cytostatic agent. It has been used mainly in the treatment of acute leukaemia, either as intravenous or intramuscular injections or as intravenous infusions at a daily level of 40–750 mg/m 2 (Weiss et al., 1972; Skoda, 1975; von Hoff et al., 1975, 1976; von Hoff & Slavik, 1977; Wade, 1977; Glover et al., 1987; Reynolds, 1989).
Azacitidine: Uses, Interactions, Mechanism of Action - DrugBank …
Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside present in DNA and RNA. 1,2 It induces antineoplastic activity by inhibiting DNA methyltransferase at low doses and inducing cytotoxicity by incorporating itself into RNA and DNA at high doses. 3,4,7