BRCA Gene Changes: Cancer Risk and Genetic Testing
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, risk-reduction, treatment, and prognosis.
Mutaciones en el gen BRCA: el riesgo de cáncer y las pruebas …
Hoja informativa sobre los genes BRCA1 y BRCA2, qué hacer si la prueba de una persona indica que tiene cambios en uno de estos genes y las consecuencias de las pruebas genéticas.
Clinical trial researching BRCA1-Associated Protein-1 mutations
2024年2月13日 · A clinical trial led by David S. Schrump, M.D., M.B.A., FACS, Chief and Senior Investigator in the Thoracic Surgery Branch, is researching a combination drug therapy for BRCA1-Associated Protein-1 mutations.
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
2024年4月15日 · Those with harmful BRCA1 or BRCA2 changes who had the surgery, the study found, had a lower risk of dying from ovarian cancer and breast cancer than those who didn’t. Results from both studies were published February 29 in JAMA Oncology.
Definition of BRCA1 gene - NCI Dictionary of Cancer Terms
A gene that makes a protein that repairs damaged DNA. Mutations (changes) in the BRCA1 gene significantly increase the risk of developing breast and ovarian cancer.
Discovery – BRCA Connection to Breast and Ovarian Cancer
NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also developed to help patients make informed decisions about their health.
Olaparib Approved for Breast Cancers with BRCA Gene Mutations
2018年1月29日 · The Food and Drug Administration has approved olaparib (Lynparza®) to treat metastatic breast cancers that have inherited mutations in the BRCA1 or BRCA2 genes as well as a companion diagnostic test for selecting candidates for the therapy.
Cancer Risk for Women Carrying BRCA Mutations - NCI
2017年7月12日 · Women who know they have inherited a harmful BRCA1 or BRCA2 mutation can take steps to reduce their risk of breast and ovarian cancer. But any preventive measures—including intensive early surveillance , use of chemoprevention , and prophylactic surgery —come with their own risks.
Definición de gen BRCA1 - Diccionario de cáncer del NCI
Gen que da origen a una proteína que repara el ADN dañado. Las mutaciones (cambios) en el gen BRCA1 aumentan mucho el riesgo de presentar cáncer de mama y cáncer de ovario.