BRCA1 - Wikipedia
BRCA1 is a human tumor suppressor gene [7] [8] (also known as a caretaker gene) and is responsible for repairing DNA. [ 9 ] BRCA1 and BRCA2 are unrelated proteins, [ 10 ] but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA , or destroy cells if DNA cannot be repaired.
BRCA Gene Changes: Cancer Risk and Genetic Testing
BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
BRCA1 and BRCA2 Mutations - StatPearls - NCBI Bookshelf
2023年7月23日 · The management of patients with a BRCA1 and BRCA2 gene mutations is individualized and can include increased surveillance, chemoprevention using tamoxifen, a bilateral prophylactic oophorectomy, and/or bilateral prophylactic mastectomy.
BRCA1 Gene - GeneCards | BRCA1 Protein | BRCA1 Antibody
5 天之前 · BRCA1 (BRCA1 DNA Repair Associated) is a Protein Coding gene. Diseases associated with BRCA1 include Breast-Ovarian Cancer, Familial 1 and Fanconi Anemia, Complementation Group S. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand …
BRCA1 - 维基百科，自由的百科全书
乳腺癌一号基因（brca1）是一种蛋白质，由在人体中编码为brca1的基因组成 [6] ，brca1是人类肿瘤抑制基因，负责修复dna。 brca1与brca2是两种不相关的蛋白质 [7] ，但通常都在乳房与其他细胞组织中出现。它们可帮助修复dna，也可在无法修复dna的情况下破坏细胞。
BRCA1 BRCA1 DNA repair associated [Homo sapiens (human)] - Gene …
2024年12月10日 · The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC).
BRCA1- and BRCA2 -Associated Hereditary Breast and Ovarian Cancer
1998年9月4日 · BRCA1- and BRCA2- associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a B...
BRCA mutation - Wikipedia
Absolute risk of cancers in BRCA1 or BRCA2 mutation. [1] A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Germline pathogenic variants in BRCA1/BRCA2 are associated with ovarian cancer, fallopian tube cancer, primary peritoneal cancer, male breast cancer, prostate cancer, pancreatic cancer, and early-onset breast cancer. BRCA1/BRCA2 -associated cancer risks are inherited in an autosomal dominant manner.
BRCA1 gene: function and deficiency - PubMed
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1.