c-Fos importance for brain development - PMC - PubMed Central …
Adult c-fos −/− mice present a ∼40–60% reduction in their body weight and their brain size is significantly smaller as compared to c-fos +/+ mice. We have shown that this correlates with a decreased brain cell number.
C-Fos - an overview | ScienceDirect Topics
C-Fos is an immediate early gene that plays a significant role in memory formation, as indicated by research findings in neuroscience. AI generated definition based on: Learning and Memory: A Comprehensive Reference, 2008
A Brief Introduction to the Transduction of Neural Activity into Fos ...
The immediate early gene c-fos has long been known as a molecular marker of neural activity. The neuron’s activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels. For the ...
Immediate Early Gene c-fos in the Brain: Focus on Glial Cells
The c-fos gene was first described as a proto-oncogene responsible for the induction of bone tumors. A few decades ago, activation of the protein product c-fos was reported in the brain after seizures and other noxious stimuli.
Review c-Fos: An AP-1 transcription factor with an additional ...
2014年9月1日 · c-Fos expression is rapidly up-regulated after addition of NGF to cultured PC12 cells which induces neuritogenesis. If together with NGF, cells are fed a Nuclear Localization Signal Peptide (NLSP) that blocks the import of AP-1 transcription factors into the nucleus, neuritogenesis is abrogated despite the fact that c-Fos is expressed normally.
C-Fos | Encyclopedia MDPI
2022年11月7日 · c-Fos is a 380 amino acid protein with a basic leucine zipper region for dimerisation and DNA-binding and a transactivation domain at C-terminus, and, like Jun proteins, it can form homodimers. In vitro studies have shown that Jun–Fos heterodimers are more stable and have stronger DNA-binding activity than Jun–Jun homodimers.
c- fos regulates neuronal excitability and survival - Nature
2002年3月4日 · Our results suggest that c-fos is a genetic regulator for cellular mechanisms mediating neuronal excitability and survival.
c-FOS: Molecular biology & detection for analysis of neuronal …
2020年9月21日 · Due to the rapid increase in levels and early response of this proto-oncogene, c-fos has been dubbed an ‘immediate early gene’ as an early responder to various cellular perturbations including electrical stimulation, exposure to serum, growth factors, and neurotransmitters.
C-Fos - an overview | ScienceDirect Topics
The fos gene (c-fos or fos) is the normal cellular gene whose retroviral derivative, v-fos, was first identified as the oncogene associated with a radiation-induced murine osteosarcoma virus (Curran and Teich, 1982; Curran et al., 1983).
Understanding c-Fos and its applications in CNS research
2024年7月31日 · What is c-Fos? c-Fos is an immediate-early gene that is activated in central nervous system (CNS) neurons upon exposure to neurotransmitters or activating stimulation. The c-Fos protein is a member of a transcription factor
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