重新审视CD8+ Tregs：具有不同表型和特性的异质群体
2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就有人研究，然而，由于缺乏特异性标志物和基因表达调节分子，导致该研究方向一度被放弃。
CD8+ Tregs revisited: A heterogeneous population with different ...
We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of …
CD8+ Regulatory T Cell – A Mystery to Be Revealed - Frontiers
2021年8月17日 · Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent autoimmune disorders. While the function and molecular regulation of Foxp3 + CD4 + Tregs are well established, much of CD8 + Treg biology remains to be revealed.
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...
CD8+ Tregs revisited: A heterogeneous population with different ...
We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of individual CD8 + T-cell subsets with proposed regulatory capacity separately.
Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for ...
Conventional cytotoxic T effector cells (Teffs) are known to be important for adaptive immune responses, particularly in the settings of viral infections and cancer. CD4+ and CD8+ Treg subsets may also share similar cytotoxic properties with conventional Teffs.
Description of CD8+ Regulatory T Lymphocytes and Their …
CD8 + Treg lymphocytes have different suppression mechanisms of cell activation and survival, using their own molecule expression: IL-2 receptor α -chain (CD25), IL-2 and IL-15 receptor β -chains (CD122), inhibitory receptor CD152 or CTLA-4, ectoenzymes CD39 and CD73 degrading ATP to ADP (CD39) and AMP to adenosine (CD73), an MHC-II-binding mole...
Immune regulation by CD8+ Treg cells: novel possibilities for ...
2018年3月5日 · Treg cells secrete several immune-modulatory cytokines (TGF-β, IL-10, TNF-α and IL-2). Tumor-induced-CD8 + Treg cells could also directly modulate activation and function of immune cells. CD8 + Treg cells may play a role in promoting imbalance of the immune system in tumor growth. These immune-tolerance mechanisms may also be exploited by ...
Type 1 Treg cells promote the generation of CD8+ tissue ... - Nature
2020年5月18日 · Here we show that type 1 regulatory T (T reg) cells, which express the transcription factor T-bet, promote the generation of CD8 + T RM cells. The absence of T-bet-expressing type 1 T reg...
Revival of CD8 + Treg–mediated suppression - Cell Press
Recent studies of these lymphocytes, now popularly referred to as regulatory CD8+ T cells (CD8+ Tregs), have helped clarify their important role in the regulation of autoimmune disease. Here, we review progress related to the identification, phenotype and function of CD8+ Tregs.