Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Caspase-8 is the initiator caspase of extrinsic apoptosis 1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality 3, which can be rescued by deletion of either Ripk3 or Mlkl 4-6. Here we show that the expression of enzymatically inactive CASP8(C362S) causes embryonic ...
The role of caspase-8 in inflammatory signalling and pyroptotic …
2023年11月1日 · Caspase-8 can cause pyroptosis through GSDMC, GSDMD and GSDME activation. The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and non-apoptotic roles.
Pyroptosis: mechanisms and diseases | Signal Transduction and …
2021年3月29日 · Hou et al. found that under hypoxia, activated p-Stat3 promoted nuclear PD-L1 translocation. Nuclear PD-L1 and p-Stat3 synergistically promote the expression of GSDMC, and caspase-8 activated by...
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
2019年11月20日 · The enzymatic activity of caspase-8 controls apoptosis, necroptosis and pyroptosis, and prevents tissue damage during embryonic development and adulthood in mice.
Caspase-8 in inflammatory diseases: a potential therapeutic target
2024年10月8日 · Caspase-8 can initiate pyroptosis independently of caspase-1 and caspase-4/5/11, potentially acting as a supplementary mechanism in the defense against infections. Additionally, caspase-8’s capacity to scaffold inflammasome assembly and activate caspase-1 further highlights its critical role in inflammatory responses.
Caspase-8: A key protein of cross-talk signal way in ... - PubMed
2021年10月1日 · In addition to mediating endogenous apoptotic pathways, caspase-8 can also participate in the cleavage of gasdermin (GSDM) family proteins to induce pyroptosis. Furthermore, the expression of enzymatically inactive caspase-8 (C362S) can cause embryonic lethality and inflammatory tissue destruction in mice by inducing necroptosis and pyroptosis.
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome …
2015年8月8日 · Results: Caspase-8 mediates IL-1β production and apoptosis by NLRP3 inflammasomes in caspase-1-deficient DC and facilitates pyroptosis in wild type DC. Conclusion: Caspase-8 is activated within NLRP3 inflammasome signaling platforms.
The role of caspase-8 in inflammatory signalling and pyroptotic …
2023年11月1日 · Caspase-8 can cause pyroptosis through GSDMC, GSDMD and GSDME activation. The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and non-apoptotic roles.
The role of caspase-8 in inflammatory signalling and ... - PubMed
2023年8月23日 · This review focuses on non-canonical caspase-8 signalling that drives immune responses, including its regulation of inflammatory gene transcription, activation within inflammasome complexes, and roles in pyroptotic cell death.
A matter of life and death for caspase 8 - Nature
2019年12月16日 · Catalytically inactive caspase 8 can activate pyroptosis when apoptosis and necroptosis are blocked, a potential line of defence against viruses that inhibit cell death.