Cationic Lipid - an overview | ScienceDirect Topics
Learn about cationic lipids, positively charged amphiphilic molecules used for delivering biologically active molecules into cells. Find chapters and articles on cationic lipid structure, properties, mechanisms, applications and interactions.
A review on cationic lipids with different linkers for gene delivery
Cationic lipids have become known as one of the most versatile tools for the delivery of DNA, RNA and many other therapeutic molecules, and are especially attractive because they can be easily designed, synthesized and characterized.
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
2021年8月10日 · Cationic lipids, ionizable lipids and other types of lipid have been explored for mRNA delivery (Fig. 2). Fig. 2: Chemical structures of lipids and lipid derivatives used for mRNA delivery.
The 60-year evolution of lipid nanoparticles for nucleic acid
2024年7月4日 · In 1985, early studies on cationic lipids, conducted by Felgner at Syntex Research Inc., resulted in the development of the first cationic lipid reagents for mRNA and plasmid DNA (pDNA) gene...
An ionizable lipid toolbox for RNA delivery - Nature
2021年12月13日 · Substitution of free amines on cationic polymers with alkyl tails affords ionizable polymer-lipids, which can enhance particle formation through hydrophobic aggregation.
Cationic lipids for gene delivery: many players, one goal
With this review, we seek to highlight the great progress made in the design of each and every constituent domain of cationic lipids, that is, the chemical structure of the headgroup, linker and hydrophobic moieties, and on the specific effect on the assembly with nucleic acids.
Permanently Charged Cationic Lipids—Evolution from Excipients …
Cationic lipids are crucial in medical and biotechnological applications including cellular transfection and gene delivery. Ionizable cationic lipids are critical components of the mRNA-based COVID vaccines while permanently charged cationic lipids have shown promise in …
Cationic lipids for gene delivery: many players, one goal
2021年3月1日 · With this review, we seek to highlight the great progress made in the design of each and every constituent domain of cationic lipids, that is, the chemical structure of the headgroup, linker and hydrophobic moieties, and on the specific effect on …
Cationic Lipid - an overview | ScienceDirect Topics
Learn about cationic lipids, amphiphilic molecules with a positive charge that can interact with nucleic acids and cell membranes. Find chapters and articles on cationic lipid-based delivery systems for DNA, siRNA, and mRNA.
Structure and Function of Cationic and Ionizable Lipids for …
Cationic lipids are amphiphilic molecules, which consist of a hydrophilic and a hydrophobic region connected by a linker structure . DOTMA and DOTAP (1,2-dioleoyl-3-trimethylammonium propane) are two most commonly investigated cationic lipids for transfection (Fig. 1).
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