The clinical features, prognostic significance, and immune ...
2021年11月11日 · Moreover, immune infiltration analyses suggested gliomas with high-expression CD37 had greater infiltration of M2 macrophages and neutrophils, and lower NK cell abundance. CD37 was closely correlated to immune checkpoint molecules, including CD276, CD80, CD86, and PD-L2.
The clinical features, prognostic significance, and immune ...
2021年11月19日 · CD37 plays a vital immunosuppressive role in glioma, and its high expression indicates a poor prognosis, which may also be attributable to the IL-6/STAT3 signaling pathway. IL-6 produced by macrophages is a well-researched protumorigenic cytokine, and its expression level is often related to the poor prognosis of tumors (Taniguchi and Karin, 2014).
Staining the target: CD37 expression in lymphomas
2016年12月29日 · CD37 has both prosurvival and proapoptotic capacities. It can mediate the clustering of α 4 β 1 integrins, which is followed by activation of PI3K/AKT signaling and cell survival. However, CD37 can also create a complex with SHP1, LYN, SYK, and PI3Kγ, leading to AKT inactivation, and recruit SOCS3, limiting the IL6/STAT3 loop.
Prognostic and immunological significance of an M1 macrophage …
2023年7月3日 · A tripartite gene signature comprising CD37, GABRD, and ARHGAP25 was an independent prognostic indicator and was employed to develop a risk score model. The internal and external validation cohort confirmed the results.
CD37: the comeback kid | Blood - American Society of Hematology
2011年10月13日 · CD 37 is a tetraspanin. It is expressed on mature B cells and very minimally expressed on T cells, monocytes, and macrophages. There is a high level of expression of CD37 across all subtypes of B-cell non-Hodgkin lymphoma.
B-Cell Targeting Anti-CD37 Humanized Antibodies Engineered for …
2022年11月15日 · Results: We revealed that the designed anti-CD37 IgG1 candidates have higher affinity towards FcγRIIa expressed on macrophages and that afucosylation enhanced FcγRIII engagement. Accordingly, using cell-based …
The clinical features, prognostic significance, and immune ...
2021年10月9日 · Functional enrichment analysis revealed CD37 was associated with immunological processes. Moreover, immune infiltration analyses suggested gliomas with high-expression CD37 had greater infiltration of M2 macrophages and neutrophils, and lower NK …
The CD37-targeted antibody-drug conjugate IMGN529 is highly …
Our in vitro studies of IMGN529 show that conjugation of the CD37-targeting K7153A antibody to DM1 does not diminish its ability to promote effector-mediated killing of CLL by NK cells and macrophages. Furthermore, both IMGN529 and K7153A greatly surpass rituximab in their ability to deplete malignant B-cells in CLL patient whole blood.
A Regulatory Role for CD37 in T Cell Proliferation1
2004年3月1日 · In humans, CD37 expression is restricted to B and T lymphocytes, monocytes, macrophages, neutrophils, dendritic cells (DC) 3, and certain leukocyte-derived malignant cells (21, 22). CD37 is not expressed by NK cells, platelets, or erythrocytes. Northern blot analyses of organs and cell lines revealed broadly similar CD37 expression in mice (23).
Tetraspanin CD37 Directly Mediates Transduction of Survival and ...
2012年5月15日 · We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expressed on mature normal and transformed B cells, becomes tyrosine phosphorylated, associates with proximal signaling molecules, and initiates …