Chaperone (protein) - Wikipedia
In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to assist large proteins in proper protein folding during or after synthesis, and after partial denaturation.
分子伴侣 - 百度百科
prion蛋白粒子病中致病性蛋白（pathogenic prion protein,PrPsc）的聚集，是因为蛋白构象中的一个或多个α螺旋变成了β片层，进入大脑后还能使正常的PrPc（normal PrP）蛋白变成异常的PrPsc蛋白，象介导错误折叠的“模板”，称为“病理性伴侣分子”（pathological chaperones ...
Chaperone (Protein) - an overview | ScienceDirect Topics
Chaperone proteins, or molecular chaperones, are proteins that assist others to fold properly during or after synthesis, to refold after partial denaturation, and to translocate to the cellular locales at which they reside and function.
Molecular chaperones in protein folding and proteostasis
2011年7月20日 · To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. Because protein molecules...
Chaperone machines for protein folding, unfolding and ... - Nature
Molecular chaperones have key roles in protein quality control and recovery from stress conditions. They assist folding and unfolding and prevent or reverse aggregation of a wide …
Chaperone machines for protein folding, unfolding and …
A set of protein families termed molecular chaperones assists various processes involving folding, unfolding and homeostasis of cellular proteins. After protein denaturation caused by stress (for example, due to heat or toxin exposure) or disease conditions, proteins can be unfolded, disaggregated and then refolded, or they can be targeted for ...
Chaperones and the Proteasome System: Regulating the …
Protein folding factors (chaperones) are required for many diverse cellular functions. In striated muscle, chaperones are required for contractile protein function, as well as the larger scale assembly of the basic unit of muscle, the sarcomere.
Molecule of the Month: Chaperones - RCSB: PDB-101
Chaperones are proteins that guide proteins along the proper pathways for folding. They protect proteins when they are in the process of folding, shielding them from other proteins that might bind and hinder the process.
Chaperone proteins: universal roles in surviving environmental …
2023年9月1日 · Chaperone proteins have crucial roles to play in all animal species and are involved in mediating both the folding of newly synthesized peptides into their mature conformation, the refolding of misfolded proteins, and the trafficking of proteins between subcellular compartments.
Pathways of chaperone-mediated protein folding in the cytosol
2004年10月1日 · For many proteins, the folding process requires the action of molecular chaperones. In the cytosol of prokaryotic and eukaryotic cells, molecular chaperones of different structural classes...